picture of green buds

Root 66

Our Story

Root 66 is your gateway to St. Louis' premier cannabis shopping experience. Expanding throughout Missouri with multiple locations opening across the state

Mission

Take the high road - providing premier cannabis shopping experience in the Midwest with quality products at affordable prices

Full suite of classic, curated and high-quality medical marijuana products. Strategically placed locations throughout St. Louis area to provide easy access to wide range of products

We We Love This Brand

Dedicated teams at each location provide excellent customer service. Color-coded binder system and knowledgeable budtenders who are well-versed in the industry

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Your fast lane to the Midwest's premier cannabis shopping experience offering classic, curated and high-quality medical marijuana products without high-end prices
Locations
Deals
States
Map
Brands
FAQs
Root 66 Dogtown
6660 Manchester Ave
St. Louis
Missouri
Visit this Location
Root 66 St. Peters
3004 S St Peters Pkwy
St Charles
Missouri
Visit this Location
Root 66 Wentzville
1163 Wentzville Pkwy
Wentzville
Missouri
Visit this Location
Root 66 Des Peres
12095 Manchester Rd
Des Peres
Missouri
Visit this Location
Root 66 S Grand
3737 S Grand Blvd
St. Louis
Missouri
Visit this Location
Root 66 Dispensary
16351 OK-66
El Reno
Oklahoma
Visit this Location
Root 66 Cannabis Dispensary Logo
Sinse eighths, 2 for $55 or 4 for $100
Root 66
Missouri
Sinse eighths, 2 for $55 or 4 for $100. Valid February 8–17 while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 17, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
30% off all local cannabis products
Root 66
Missouri
30% off all local cannabis products. Available on Fridays and Saturdays throughout February while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 24, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
2 for $80 Amaze disposable vapes
Root 66
Missouri
Amaze disposable vapes, 2 for $80, South Grand location only. Valid in February while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 24, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
25% off Sinse live resin carts, LR AIOs, Juicy products, and concentrates
Root 66
Missouri
25% off Sinse live resin carts, LR AIOs, Juicy products, and concentrates. Valid February 18–24 while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 24, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
25% off all Vertical products
Root 66
Missouri
25% off all Vertical products. Valid February 6–8 and February 20–22 while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 22, 2026
Cannabis
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Root 66 Cannabis Dispensary Logo
Curio flower deals including 2 for $45 eighths, 2 for $80 7g, and 2 for $140 14g
Root 66
Missouri
Curio flower deals including 2 for $45 eighths, 2 for $80 7g, and 2 for $140 14g. Available all February while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 24, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
25% off Amaze, Nugz, and Acute products
Root 66
Missouri
25% off Amaze, Nugz, and Acute products. Excludes shake and rosin-infused pre-rolls. Valid February 7–13 and February 21–27 while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 27, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
Happy Eddie 2-pack pre-rolls, 2 for $20
Root 66
Missouri
Happy Eddie 2-pack pre-rolls, 2 for $20. Available all February while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 24, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
20% off Sundro, Atta, & Hugs products
Root 66
Missouri
20% off Sundro, Atta, & Hugs products. Valid February 8 - 14 while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 14, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
25% off all Airo products
Root 66
Missouri
25% off all Airo products. Valid February 16–22 while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 22, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
Buy one get one for 1 cent on Vibe 100mg gummies
Root 66
Missouri
Buy one get one for 1 cent on Vibe 100mg gummies. Valid February 14 only while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 14, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
Edie Parker 1/8ths, 2 for $60
Root 66
Missouri
Edie Parker 1/8ths, 2 for $60. Available all February while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 24, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
25% off all Robust and Packs products
Root 66
Missouri
25% off all Robust and Packs products. Valid February 1–7 and February 22–28 while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 28, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
20% off all Happy Eddie products
Root 66
Missouri
20% off all Happy Eddie products. Available on Fridays and Saturdays throughout February while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 24, 2026
Cannabis
More Info
Root 66 Cannabis Dispensary Logo
30% off all Sinse concentrates only at Des Peres location
Root 66
Missouri
30% off all Sinse concentrates only at Des Peres location. Valid in February while supplies last. Cannot be combined with other offers.
Valid From:
February 24, 2026
Valid Until:
February 24, 2026
Cannabis
More Info
Missouri
Dispensary URL
https://root66cannabis.com/locations/
Is there a loyalty program?

Yes - Highway Mile Points loyalty program with exclusive promotions and deals

Do you need a promo code for deals?

No - automatic application, app provides real-time notifications

Do they deliver?

Information not specified - focus on in-store experience

Always check with the dispensaries to confirm validity. They reserve the right to change/remove any offers. Offers may have other stipulations and limitations. Dispensaries and CalmEffect are not responsible for any typos or mistakes. Specials typically cannot be combined with other offers or points unless stated. Product availability can differ by location. Other restrictions may apply.

Your fast lane to the Midwest's premier cannabis shopping experience offering classic, curated and high-quality medical marijuana products without high-end prices